Bioequivalence Study of Cyclosporine 100mg Capsule Under Fed Condition

August 22, 2020at 11:17 am | Author : Ashley | Category : Antibodies, Assay Kits, Biology Cells, cDNA, Clia Kits, Culture Cells, Devices, DNA, DNA Templates, Elisa Kits, Enzymes, Equipments, Exosomes, Gels, Isotypes, Medium & Serums, NATtrol, Panel, Particles, PCR, Pcr Kits, Peptides, Reagents, Recombinant Proteins, Ria Kits, RNA, Test Kits, Vector & Virus, Western Blot | : Thumbtack

Bioequivalence Research of Cyclosporine 100mg Capsule Below Fed Situation

Complete 78 regular wholesome grownup male topics can be enrolled within the research. Topics can be administered both the Take a look at or the Reference Product with 240 mL of water in every interval as per the randomization schedule. Topics will quick for a minimum of 10 hours previous to Excessive Fats Breakfast half an hour earlier than administration of the research drug and for 4 (4) further hours every, put up dose throughout every research interval.

Standardized meals can be offered in every research interval. Water won’t be accessible to the themes 1 hour Predose and a couple of hours Submit dose in every interval. A complete of 24 blood samples can be withdrawn for pharmacokinetic profiling. The entire blood concentrations of Cyclosporine can be measured by a validated LC/MS/MS analytical methodology.

Ratio evaluation can be carried out for untransformed and log remodeled pharmacokinetic parameters Cmax, AUC0-72, AUC0 inf. ANOVA can be carried out on log remodeled pharmacokinetic parameters Cmax, AUC0-72, AUC0-inf and 90% confidence interval can be constructed for the ratio of geometric least sq. imply of the Take a look at and Reference merchandise, obtained from the log-transformed knowledge.

Bioequivalence can be concluded if the ratio estimate in addition to its 90% confidence interval, each falls throughout the acceptable vary of 80.00% to 125.00% for Cmax, AUC0-72 and AUC0-inf

Histone H3 Peptide (residues 1-21)
R-1003	EpiGentek	EUR 267.06 EUR 78.10 EUR 140.80	400 µl 200 ul 400 ul

Histone H3 Peptide (residues 1-21), Biotinylated
R-1004	EpiGentek	EUR 267.06 EUR 78.10 EUR 140.80	200 µl 100 ul 200 ul

Histone H3 Peptide (residues 15-39)
R-1005	EpiGentek	EUR 303.60 EUR 94.60 EUR 165.00	200 µl 100 ul 200 ul

Histone H3 Peptide (residues 21-44), Biotinylated
R-1006	EpiGentek	EUR 362.76 EUR 119.90 EUR 205.70	200 µl 100 ul 200 ul

Histone H4 Peptide (residues 1-21), Biotinylated
R-1007	EpiGentek	EUR 361.02 EUR 119.90 EUR 204.60	200 µl 100 ul 200 ul

Histone Acetyl H4ac Peptide, Biotinylated
R-1008	EpiGentek	EUR 361.02 EUR 119.90 EUR 204.60	200 µl 100 ul 200 ul

Histone Acetyl H3K9ac Peptide
R-1009	EpiGentek	EUR 267.06 EUR 78.10 EUR 140.80	200 µl 100 ul 200 ul

Histone Acetyl H3K9ac Peptide, Biotinylated
R-1010	EpiGentek	EUR 361.02 EUR 119.90 EUR 204.60	200 µl 100 ul 200 ul

Histone Acetyl H3K14ac Peptide
R-1011	EpiGentek	EUR 267.06 EUR 78.10 EUR 140.80	200 µl 100 ul 200 ul

Histone Acetyl H3K14ac Peptide, Biotinylated
R-1012	EpiGentek	EUR 361.02 EUR 119.90 EUR 204.60	200 µl 100 ul 200 ul

Histone Acetyl H4K5ac Peptide
R-1014	EpiGentek	EUR 267.06 EUR 78.10 EUR 140.80	200 µl 100 ul 200 ul

Histone Acetyl H4K8ac Peptide
R-1015	EpiGentek	EUR 267.06 EUR 78.10 EUR 140.80	200 µl 100 ul 200 ul

Histone Acetyl H4K12ac Peptide
R-1016	EpiGentek	EUR 267.06 EUR 78.10 EUR 140.80	200 µl 100 ul 200 ul

Histone Acetyl H4K16ac Peptide
R-1017	EpiGentek	EUR 267.06 EUR 78.10 EUR 140.80	200 µl 100 ul 200 ul

Histone H3K4me1 Monomethyl Peptide
R-1018	EpiGentek	EUR 341.88 EUR 106.70 EUR 191.40	200 µl 100 ul 200 ul

Histone H3K4me1 Monomethyl Peptide, Biotinylated
R-1019	EpiGentek	EUR 361.02 EUR 119.90 EUR 204.60	200 µl 100 ul 200 ul

Histone H3K4me2 Dimethyl Peptide
R-1020	EpiGentek	EUR 267.06 EUR 78.10 EUR 140.80	200 µl 100 ul 200 ul

Histone H3K4me2 Dimethyl Peptide, Biotinylated
R-1021	EpiGentek	EUR 361.02 EUR 119.90 EUR 204.60	200 µl 100 ul 200 ul

Histone H3K4me3 Trimethyl Peptide
R-1022	EpiGentek	EUR 341.88 EUR 106.70 EUR 191.40	200 µl 100 ul 200 ul

Histone H3K4me3 Trimethyl Peptide, Biotinylated
R-1023	EpiGentek	EUR 361.02 EUR 119.90 EUR 204.60	200 µl 100 ul 200 ul

Histone H3K9me1 Monomethyl Peptide
R-1024	EpiGentek	EUR 341.88 EUR 106.70 EUR 191.40	200 µl 100 ul 200 ul

Histone H3K9me1 Monomethyl Peptide, Biotinylated
R-1025	EpiGentek	EUR 361.02 EUR 119.90 EUR 204.60	200 µl 100 ul 200 ul

Histone H3K9me2 Dimethyl Peptide
R-1026	EpiGentek	EUR 341.88 EUR 106.70 EUR 191.40	200 µl 100 ul 200 ul

Histone H3K9me2 Dimethyl Peptide, Biotinylated
R-1027	EpiGentek	EUR 361.02 EUR 119.90 EUR 204.60	200 µl 100 ul 200 ul

Histone H3K9me3 Trimethyl Peptide
R-1028	EpiGentek	EUR 341.88 EUR 106.70 EUR 191.40	200 µl 100 ul 200 ul

Histone H3K9me3 Trimethyl Peptide, Biotinylated
R-1029	EpiGentek	EUR 361.02 EUR 119.90 EUR 204.60	200 µl 100 ul 200 ul

Histone H3K27me1 Monomethyl Peptide
R-1030	EpiGentek	EUR 341.88 EUR 106.70 EUR 191.40	200 µl 100 ul 200 ul

Histone H3K27me1 Monomethyl Peptide, Biotinylated
R-1031	EpiGentek	EUR 361.02 EUR 119.90 EUR 204.60	200 µl 100 ul 200 ul

Histone H3K27me2 Dimethyl Peptide
R-1032	EpiGentek	EUR 341.88 EUR 106.70 EUR 191.40	200 µl 100 ul 200 ul

Histone H3K27me2 Dimethyl Peptide, Biotinylated
R-1033	EpiGentek	EUR 361.02 EUR 119.90 EUR 204.60	200 µl 100 ul 200 ul

Histone H3K27me3 Trimethyl Peptide
R-1034	EpiGentek	EUR 341.88 EUR 106.70 EUR 191.40	200 µl 100 ul 200 ul

Histone H3K27me3 Trimethyl Peptide, Biotinylated
R-1035	EpiGentek	EUR 361.02 EUR 119.90 EUR 204.60	200 µl 100 ul 200 ul

Histone H3K36me1 Monomethyl Peptide
R-1036	EpiGentek	EUR 341.88 EUR 106.70 EUR 191.40	200 µl 100 ul 200 ul

Histone H3K36me1 Monomethyl Peptide, Biotinylated
R-1037	EpiGentek	EUR 361.02 EUR 119.90 EUR 204.60	200 µl 100 ul 200 ul

Histone H3K36me2 Dimethyl Peptide
R-1038	EpiGentek	EUR 341.88 EUR 106.70 EUR 191.40	200 µl 100 ul 200 ul

Histone H3K36me3 Trimethyl Peptide
R-1039	EpiGentek	EUR 341.88 EUR 106.70 EUR 191.40	200 µl 100 ul 200 ul

Histone H4K20me1 Monomethyl Peptide
R-1043	EpiGentek	EUR 341.88 EUR 106.70 EUR 191.40	200 µl 100 ul 200 ul

Histone H4K20me2 Dimethyl Peptide
R-1044	EpiGentek	EUR 341.88 EUR 106.70 EUR 191.40	200 µl 100 ul 200 ul

Histone H4K20me3 Trimethyl Peptide
R-1045	EpiGentek	EUR 341.88 EUR 106.70 EUR 191.40	200 µl 100 ul 200 ul

Biotinylated Phospho Histone Ser 10 Peptide
R-1047	EpiGentek	EUR 361.02 EUR 119.90 EUR 204.60	200 µl 100 ul 200 ul

Histone H3K36me2 Dimethyl Peptide, Biotinylated
R-1049	EpiGentek	EUR 361.02 EUR 119.90 EUR 204.60	200 µl 100 ul 200 ul

Histone H3K36me3 Trimethyl Peptide, Biotinylated
R-1050	EpiGentek	EUR 361.02 EUR 119.90 EUR 204.60	200 µl 100 ul 200 ul

Histone H3K79me1 Monomethyl Peptide, Biotinylated
R-1051	EpiGentek	EUR 361.02 EUR 119.90 EUR 204.60	200 µl 100 ul 200 ul

Histone H3K79me2 Dimethyl Peptide, Biotinylated
R-1052	EpiGentek	EUR 361.02 EUR 119.90 EUR 204.60	200 µl 100 ul 200 ul

Histone H4K20me1 Monomethyl Peptide, Biotinylated
R-1054	EpiGentek	EUR 361.02 EUR 119.90 EUR 204.60	200 µl 100 ul 200 ul

Histone H4K20me3 Trimethyl Peptide, Biotinylated
R-1056	EpiGentek	EUR 361.02 EUR 119.90 EUR 204.60	200 µl 100 ul 200 ul

Nucleic Acid Isolation Enhancer (Glycogen Solution)
R-1001	EpiGentek	EUR 164.40 EUR 75.90	500 µl 500 ul

Methylamp PCR Enhancer
R-1002	EpiGentek	EUR 185.28 EUR 90.20	400 Reactions 400 Reactions

Streptavidin: HRP Conjugate
R-1098	EpiGentek	EUR 218.34 EUR 107.80	0.5 ml 0.5 ml

Streptavidin
R-1100	EpiGentek	EUR 237.48 EUR 121.00	1 mg 1 ml

Protease Inhibitor Cocktail
R-1101	EpiGentek	EUR 176.58 EUR 79.20	1 ml 1 ml

Streptavidin-Coated Strip Microwell Plate (Flat)
R-1102	EpiGentek	EUR 361.02 EUR 204.60	5/pk 5/pk

DNA High Binding Solution
R-1103	EpiGentek	EUR 267.06 EUR 140.80	30 ml 30 ml

DTT Solution
R-1104	EpiGentek	EUR 131.34 EUR 48.40	1 ml, 500 mM 1 ml, 500 mM

Histone H3K79me3 Trimethyl Peptide, Biotinylated
R-1053	EpiGentek	EUR 116.60 EUR 198.00	100 ul 200 ul

Histone H4K20me1 Dimethyl Peptide, Biotinylated
R-1055	EpiGentek	EUR 116.60 EUR 198.00	100 ul 200 ul

Coomassie Brilliant Blue G250
abx090654-5g	Abbexa	5 g	EUR 226.8

Coomassie Brilliant Blue R250
abx090655-5g	Abbexa	5 g	EUR 226.8

Coomassie Brilliant Blue Solution
GR103030	Genorise Scientific	100 mL	EUR 99.6

OPTIONAL BLUE FILTER (497NM)
GDBL-BLUE	CORNING	1/pk	EUR 1298.4
Description: Lab Equipment; Axygen Branded EQ

conversion screen uv/blue
VLFC26-BLUE	Consort	ea	EUR 727.2

Coomassie brilliant blue G-250
20-abx082402	Abbexa	EUR 276.00 EUR 226.80	25 g 5 g

Coomassie brilliant blue G-250
20-abx082562	Abbexa	EUR 260.40 EUR 210.00	25 g 5 g

Brilliant Cresyl Blue (0.3%, Alcoholic)
BCA3800	ScyTek Laboratories	1 Gal.	EUR 289.2

Brilliant Cresyl Blue (0.3%, Alcoholic)
BCA500	ScyTek Laboratories	500 ml	EUR 108

Brilliant Cresyl Blue (0.3%, Alcoholic)
BCA999	ScyTek Laboratories	1000 ml	EUR 139.2

Coomassie brilliant blue G-250
CB0038	Bio Basic	25g	EUR 90.28

Brilliant Cresyl Blue (C.I. 51010)
GT9275-10G	Glentham Life Sciences	10 g	EUR 103.2

Brilliant Cresyl Blue (C.I. 51010)
GT9275-25G	Glentham Life Sciences	25 g	EUR 132

Coomassie Brilliant Blue Fast Staining Solution
abx090652-200ml	Abbexa	200 ml	EUR 243.6

Coomassie Brilliant Blue Gel Staining Kit
abx090653-1Kit	Abbexa	1 Kit	EUR 226.8

Coomassie Brilliant Blue G250 (C.I. 42655)
GT0353-100G	Glentham Life Sciences	100 g	EUR 151.2

Coomassie Brilliant Blue G250 (C.I. 42655)
GT0353-25G	Glentham Life Sciences	25 g	EUR 74.4

Coomassie Brilliant Blue G250 (C.I. 42655)
GT0353-5G	Glentham Life Sciences	5 g	EUR 55.2

Coomassie Brilliant Blue R250 (C.I. 42660)
GT3543-100G	Glentham Life Sciences	100 g	EUR 151.2

Coomassie Brilliant Blue R250 (C.I. 42660)
GT3543-25G	Glentham Life Sciences	25 g	EUR 74.4

Coomassie Brilliant Blue R250 (C.I. 42660)
GT3543-5G	Glentham Life Sciences	5 g	EUR 55.2

Brilliant Cresyl Blue (1.5% in 0.85% Saline)
BCS3800	ScyTek Laboratories	1 Gal.	EUR 289.2

Brilliant Cresyl Blue (1.5% in 0.85% Saline)
BCS500	ScyTek Laboratories	500 ml	EUR 108

Brilliant Cresyl Blue (1.5% in 0.85% Saline)
BCS999	ScyTek Laboratories	1000 ml	EUR 139.2

1000UL BLUE TIPS, RACKED AND PRE-STERILIZED
T-1000-B-R-S	CORNING	1000/pk	EUR 210
Description: Non Filter Tips; Pipette Tips - Axygen

10G Coomassie Blue R-250
NAT1360	Scientific Laboratory Supplies	10G	EUR 72.96

Brilliant green
BB0242	Bio Basic	25g	EUR 67.31

Apex IPTG 5g Biotechnology Grade
20-109	Genesee Scientific	5g/Unit	EUR 293

1000UL BLUE TIPS COMPATIBLE WITH EPPENDORF AND SOCOREX PIPETTORS.
TE-1004-B-R	CORNING	1152/pk	EUR 254.4
Description: Non Filter Tips; Pipette Tips - Axygen

Bioequivalence Research of Tacrolimus 1 mg Capsule Below Fasting Situation

Complete 36 regular wholesome grownup male topics can be enrolled within the research. Topics can be administered both the Take a look at or the Reference Product with 240 mL of water in every interval as per the randomization schedule.

Topics will quick for a minimum of 10 hours previous to dose administration and for a minimum of Four hours put up dose. Standardized meals can be offered in every research interval. Water won’t be accessible to the themes 1 hour Predose and a couple of hours Submit dose in every interval.

A complete of 23 blood samples can be withdrawn for pharmacokinetic profiling. The entire blood concentrations of Tacrolimus can be measured by a validated LC/MS/MS analytical methodology. Ratio evaluation can be carried out for untransformed and log remodeled pharmacokinetic parameters Cmax, AUC0-72, AUC0 inf. ANOVA can be carried out on log remodeled pharmacokinetic parameters Cmax, AUC0-72, AUC0-inf and 90% confidence interval can be constructed for the ratio of geometric least sq. imply of the Take a look at and Reference merchandise, obtained from the log-transformed knowledge.

Bioequivalence can be concluded if the ratio estimate in addition to its 90% confidence interval, each falls throughout the acceptable vary of 80.00% to 125.00% for Cmax, AUC0-72 and AUC0-inf.

Bioequivalence Research of Tacrolimus 1 mg Capsule Below Fed Situation

Complete 36 regular wholesome grownup male topics can be enrolled within the research. Topics can be administered both the Take a look at or the Reference Product with 240 mL of water in every interval as per the randomization schedule.

Topics will quick for a minimum of 10 hours previous to Excessive Fats Breakfast half an hour earlier than administration of the research drug and for 4 (4) further hours every, put up dose throughout every research interval. Standardized meals can be offered in every research interval.

Water won’t be accessible to the themes 1 hour Predose and a couple of hours Submit dose in every interval. A complete of 26 blood samples can be withdrawn for pharmacokinetic profiling.

The entire blood concentrations of Tacrolimus can be measured by a validated LC/MS/MS analytical methodology. Ratio evaluation can be carried out for untransformed and log remodeled pharmacokinetic parameters Cmax, AUC0-72, AUC0 inf. ANOVA can be carried out on log remodeled pharmacokinetic parameters Cmax, AUC0-72, AUC0-inf and 90% confidence interval can be constructed for the ratio of geometric least sq. imply of the Take a look at and Reference merchandise, obtained from the log-transformed knowledge.

Bioequivalence can be concluded if the ratio estimate in addition to its 90% confidence interval, each falls throughout the acceptable vary of 80.00% to 125.00% for Cmax, AUC0-72 and AUC0-inf

Product not found

Bioequivalence Study of Cyclosporine 100mg Capsule Under Fed Condition

Bioequivalence Research of Cyclosporine 100mg Capsule Below Fed Situation

Histone H3 Peptide (residues 1-21)

Histone H3 Peptide (residues 1-21), Biotinylated

Histone H3 Peptide (residues 15-39)

Histone H3 Peptide (residues 21-44), Biotinylated

Histone H4 Peptide (residues 1-21), Biotinylated

Histone Acetyl H4ac Peptide, Biotinylated

Histone Acetyl H3K9ac Peptide

Histone Acetyl H3K9ac Peptide, Biotinylated

Histone Acetyl H3K14ac Peptide

Histone Acetyl H3K14ac Peptide, Biotinylated

Histone Acetyl H4K5ac Peptide

Histone Acetyl H4K8ac Peptide

Histone Acetyl H4K12ac Peptide

Histone Acetyl H4K16ac Peptide

Histone H3K4me1 Monomethyl Peptide

Histone H3K4me1 Monomethyl Peptide, Biotinylated

Histone H3K4me2 Dimethyl Peptide

Histone H3K4me2 Dimethyl Peptide, Biotinylated

Histone H3K4me3 Trimethyl Peptide

Histone H3K4me3 Trimethyl Peptide, Biotinylated

Histone H3K9me1 Monomethyl Peptide

Histone H3K9me1 Monomethyl Peptide, Biotinylated

Histone H3K9me2 Dimethyl Peptide

Histone H3K9me2 Dimethyl Peptide, Biotinylated

Histone H3K9me3 Trimethyl Peptide

Histone H3K9me3 Trimethyl Peptide, Biotinylated

Histone H3K27me1 Monomethyl Peptide

Histone H3K27me1 Monomethyl Peptide, Biotinylated

Histone H3K27me2 Dimethyl Peptide

Histone H3K27me2 Dimethyl Peptide, Biotinylated

Histone H3K27me3 Trimethyl Peptide

Histone H3K27me3 Trimethyl Peptide, Biotinylated

Histone H3K36me1 Monomethyl Peptide

Histone H3K36me1 Monomethyl Peptide, Biotinylated

Histone H3K36me2 Dimethyl Peptide

Histone H3K36me3 Trimethyl Peptide

Histone H4K20me1 Monomethyl Peptide

Histone H4K20me2 Dimethyl Peptide

Histone H4K20me3 Trimethyl Peptide

Biotinylated Phospho Histone Ser 10 Peptide

Histone H3K36me2 Dimethyl Peptide, Biotinylated

Histone H3K36me3 Trimethyl Peptide, Biotinylated

Histone H3K79me1 Monomethyl Peptide, Biotinylated

Histone H3K79me2 Dimethyl Peptide, Biotinylated

Histone H4K20me1 Monomethyl Peptide, Biotinylated

Histone H4K20me3 Trimethyl Peptide, Biotinylated

Nucleic Acid Isolation Enhancer (Glycogen Solution)

Methylamp PCR Enhancer

Streptavidin: HRP Conjugate

Streptavidin

Protease Inhibitor Cocktail

Streptavidin-Coated Strip Microwell Plate (Flat)

DNA High Binding Solution

DTT Solution

Histone H3K79me3 Trimethyl Peptide, Biotinylated

Histone H4K20me1 Dimethyl Peptide, Biotinylated

Coomassie Brilliant Blue G250

Coomassie Brilliant Blue R250

Coomassie Brilliant Blue Solution

OPTIONAL BLUE FILTER (497NM)

conversion screen uv/blue

Coomassie brilliant blue G-250

Coomassie brilliant blue G-250

Brilliant Cresyl Blue (0.3%, Alcoholic)

Brilliant Cresyl Blue (0.3%, Alcoholic)

Brilliant Cresyl Blue (0.3%, Alcoholic)

Coomassie brilliant blue G-250

Brilliant Cresyl Blue (C.I. 51010)

Brilliant Cresyl Blue (C.I. 51010)

Coomassie Brilliant Blue Fast Staining Solution

Coomassie Brilliant Blue Gel Staining Kit

Coomassie Brilliant Blue G250 (C.I. 42655)

Coomassie Brilliant Blue G250 (C.I. 42655)

Coomassie Brilliant Blue G250 (C.I. 42655)

Coomassie Brilliant Blue R250 (C.I. 42660)

Coomassie Brilliant Blue R250 (C.I. 42660)

Coomassie Brilliant Blue R250 (C.I. 42660)

Brilliant Cresyl Blue (1.5% in 0.85% Saline)